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BLOOD TYPES
BLOOD TYPES Type of antigens present on RBC membranes Not discovered until 1901 by Landsteiner At least 14 human blood group systems ABO is most important, Rh is 2nd in importance M and N antigens are inherited the same way A and B are, but both genes are dominant and there is no recessive gene - thus the only possible types are M, N and MN Of little medical importance because few people produce anti-M or anti-N antibodies even after repeated exposures to the antigens System is of interest to geneticists and anthropologists Landsteiner in 1927 discovered the M and N factors and in 1940, at age 72, discovered the
MAJOR BLOOD TYPES
Plasma never contains antibodies against the antigens present on its own RBCs, but it does contain antibodies to other antigens
Rare instance of preformation of antibodies without prior exposure
In the embryo antigens are found on the RBCs about the 6th week
At birth the concentration is about 1/5 the adult level
Normal concentrations are reached during adolescence
Antibodies (IgM) are gamma globulins in plasma - 6% of all plasma antibodies
Not present at birth
Are formed in 1st 2 weeks of life
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