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NUTRIENTS IN PLASMA
End products of digestion - amino acids, glucose and neutral fats Glucose concentration is 80 - 120 mg per 100 ml of blood Fats occur in plasma in form of small particles called chylomicrons Cholesterol in plasma In adult concentration should not exceed 250 mg per 100 ml Desirable level is less than 200 mg/100 ml (Average U.S. value=205 mg/100 ml) Borderline high-risk=200-239 mg/100 ml High risk=more than 240 mg/100 ml Familial hyperlipidemia - concentration may reach 1000 mg/100 ml - high incidence of atherosclerosis and heart disease Cholesterol is found in all tissues and body fluids - 2 sources: 2. Formation in cells (especially liver cells) - endogenous cholesterol Used by liver to form cholic acid which helps form bile salts adrenal gland to form cortical hormones ovaries to form progesterone and estrogen testes to form testosterone Large amounts in skin to prevent water evaporation, etc. Plasma cholesterol is complexed with lipoproteins The risk of heart attack may be due to form which cholesterol is being transported rather than total level LDL (low density lipoprotein) transports cholesterol from liver to body cells Excess LDL - cholesterol deposited in artery walls – atherosclerosis Desirable level – less than 130 mg/100 ml Borderline high-risk – 130-159 mg/100 ml High risk – more than 160 mg/100 ml HDL (high density lipoprotein) removes cholesterol from artery walls and prevents its deposition Desirable level – 60 mg or more/100 ml Risk factor – below 35 mg/100 ml Recommended ratio of total cholesterol/HDL - Less than 4 – males, less than 3.5 - females
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