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PLASMA PROTEINS
PLASMA PROTEINS Normal concentration of plasma proteins is 6-8 g per 100 ml of plasma Plasma proteins contribute to the solution and transport of lipids, fat-soluble vitamins, bile salts and hormones in the blood and help regulate acid - base balance 3 major types of proteins in plasma: 1. Serum albumin – 55-60% of total plasma proteins - largely responsible for blood viscosity Smallest plasma proteins Albumin is especially important in maintaining blood volume Responsible for osmotic (“pull”) pressure of the plasma Essential for holding and pulling water from the tissue fluid into blood vessels A decrease in plasma proteins can result in edema (accumulation of fluid in tissues) If serum albumin leaks from capillaries as a result of injury (severe burn), water cannot be retained and blood volume and pressure drop-shock may result Treat with intravenous injection of serum albumin 2. Serum globulin –36-38% of total plasma proteins-include: Opsonins-facilitate phagocytosis by WBCs Alpha globulins-antithrombin Beta globulins-clotting factors Alpha and beta globulins also transport lipids and other substances in blood Gamma globulins-antibodies Prothrombin 3. Fibrinogen – 4-7% of total plasma proteins - largest plasma protein molecule Practically all the serum albumin and fibrinogen are formed in liver Globulins are formed by the liver (Ex. Alpha and beta globulins) and the lymphatic system (Ex. Gamma globulins are synthesized by plasma cells)
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